Oromucosal delivery especially that utilizing the buccal and sublingual mucosa as the absorption site, is a promising drug delivery route which promotes rapid absorption and high bioavailability, with subsequent almost immediate onset of pharmacological effect. These advantages are the result of the highly vascularized oral mucosa through which drugs enter the systemic circulation directly, thus bypassing the gastrointestinal tract and the first pass effect in the liver. Tablets are the most common solid dosage form, administered orally, but many patients specially children, mentally ill patients and geriatrics have problem in swallowing the tablets. Mouth dissolving tablets (MDT) have advantage of ease of administration and rapid onset of action. Further there is advantage of rapid disintegration without use of water in oral cavity. When MDT is kept in oral cavity then saliva quickly penetrates into tablet pores and causes rapid disintegration. To mask the bitterness of drug various techniques are available, among those taste masking by use of ion exchange resin is most commonly used commercially. Ion exchange resins (IERs) are used to mask bitter taste of drug. They are solid and insoluble high molecular weight poly electrolytes capable of exchange of their ions with the counter ion in the surrounding medium. In present study an attempt was made to mask the taste of tenoxicam with formulation of mouth dissolving tablet having desired good characteristics of MDT so as to give pleasant taste and good bioavailability. Complexation with cation-exchange resin, Indion 204 resemblance to taste masking of tenoxicam. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25 ml of water with 5 min stirring time. Drug-resin complexes were characterized for dissolution studies. Drug release from drug-resin complex in salivary pH was insufficient to impart bitter taste. The new sublingual tablet concept presented is based on interactive mixtures consisting of a water-soluble carrier covered with fine drug particles and a bioadhesive component. With this approach, it is possible to obtain rapid dissolution in combination with bioadhesive retention of the drug in the oral cavity. Optimized orally disintegrating tablets (ODTs) containing tenoxicam) were prepared by direct compression method. And characterized for hardness, disintegration time, friability and wetting time. Box-Behnken statistically designed with 3 factors, 3 levels and 15 run was selected to statistically optimized the formulation parameters and evaluate the main, quadratic and interaction effects of the preparations. The manufactured ODTs were complying with the pharmacopeia guidelines regarding hardness, friability, weight variation and content.
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